The morphogenetic model is based on the structure
of the cortex as a closed surface with glial and axonal
fibres pulling radially, the fundamental mechanical
properties of cortex and fibres (elasticity and plasticity),
and the growth of the cortical surface. The application
illustrated several aspects of folding development, such as the
relationship between cortical surface and brain volume,
the compensation in the degree of
folding and the dependence of the degree of folding on cortical
thickness. It also shows the effect on folding of early cortical
regionalisation and global brain geometry.
References Toro R and Burnod Y (2005) A Morphogenetic Model for the Development of Cortical Convolutions. Cerebral Cortex [Link] Toro R (2012) On the possible shapes of the brain. Evol Biol |
last update 20 october 2012, roberto toro
génétique humaine et fonctions cognitives | institut pasteur | paris, FR
génétique humaine et fonctions cognitives | institut pasteur | paris, FR